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This dual functionality enables both stem cell pool expansion and directed differentiation depending on copper availability, providing remarkable versatility in regenerative applications

Nevertheless, if its senolytic action has been demonstrated in several diseases such as osteoarthritis 15,16 as well as in neurodegenerative diseases 17 , the effect of ABT-263 is restricted to senescent cells from specific cell types 18 , leading to the necessity to identify new potential senolytics to target senescent cells in age-related diseases

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HGF is the only ligand for the tyrosine kinase receptor encoded by the MET proto-oncogene (Bottaro et al., 1991