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The diverse roles of histamine are orchestrated by its interaction with different receptor types: H1 Receptors: Primarily involved in allergic reactions, causing smooth muscle contraction (e.g., bronchoconstriction), vasodilation, and increased vascular permeability

Animal procedures were conducted in accordance with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines and approved by the Institutional Animal Care and Use Committee of the Affiliated Hospital of Qingdao University [AHQU-MAL20230607LH]

Thus, DNTB method grants measurement of free GSH, oxidized GSH (GSSG) and total content of GSH (free GSH + GSSG) in a multi-step approach in biological samples

The PHOX designation refers to phagocyte oxidase