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10.3390/biomedicines13010018 24 De RosaS

3,4 This receptor and its agonists hold significant therapeutic potential, reshaping the treatment approaches for multiple diseases, including diabetes, cardiovascular disorders, and neurodegenerative diseases

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Apart from multifactorial interventions, alternatives to caloric restriction can include environmental conditioning and caloric restriction mimetics, including rapamycin, metformin, or a blend of micronutrients and bioactives, including quercetin, rutin, curcumin, genistein, resveratrol, epigallocatechin gallate, gallic acid, betaine, theanine, -aminobutyric acid, diallyl sulforated compounds, NAD + precursors, coenzyme Q10, vitamins, plant polysaccharide, plant-derived peptides, and others