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The mechanism appears to be interference with erythropoiesis

Studies on the effects of Ang A, a recently discovered novel human Ang-derived peptide, where only the N-terminal amino acid is different from Ang II, have also yielded conflicting results

When used in combination with a vascular disrupting agent (CA4-NPs) to boost tumor fibrin deposition and intensify hypoxia, this nanodrug achieved remarkable efficacy: a 98.1% inhibition rate in CT26 tumor models (initial volume ~480 mm) and complete eradication of tumors in 4 out of 6 treated subjects after a single dose (288)