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[DOI] [PMC free article] [PubMed] [Google Scholar] Benchoam D

On average (dependent on the parasitemia of each individual experiment), the percentage of DHA remaining inactivated in artemisinin resistant parasites (Cam3.II R539T and MRA1240) following a 2 h incubation was significantly higher (2-fold greater) than sensitive (Cam3.II REV and MRA1239) (Fig 3F)

Notably, we generated various N-terminal truncation constructs for SnCE1, i.e., SnCE1 74-310 , SnCE1 85-310 , SnCE1 95-310 and SnCE1 104-310 , the catalytically inactive mutant SnCE1 C256A and the reported gatekeeper mutant SnCE1 W191A (Fig