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The applicant stated that ICD-10-CM codes F32.2 (Major depressive disorder, single episode, severe without psychotic features) and F33.2 (Major depressive disorder, recurrent severe without psychotic features) may be used to currently identify the indication for the SAINT Neuromodulation System under the ICD-10-CM coding system

Moreover, this process stimulates the release of cytokines like IL-17 A, IL-21, NF-B, and TNF-, resulting in elevated levels of chemokines, adhesion molecules, and matrix metalloproteinases (MMP)