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How GHK-Cu Works (Mechanism of Action) GHK-Cu functions primarily as: A copper delivery molecule A modulator of gene expression A regulator of extracellular matrix remodelling Copper is an essential cofactor for enzymes involved in: Collagen cross-linking Angiogenesis Antioxidant defense Tissue remodelling GHK-Cu appears to: Increase synthesis of collagen types I and III Stimulate dermal fibroblast activity Modulate matrix metalloproteinases (MMPs) Reduce pro inflammatory signalling in wound models Its effects are local and tissue specific rather than systemic and hormonal