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PUFAs are integral components of the phospholipid bilayer, influencing lipid dynamics, protein-lipid interactions, and membrane transport properties (Dyall et al., 2022)

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Common upstream drivers in Hashimotos Gluten and cross-reactive foods in susceptible individuals Intestinal permeability (leaky gut) and mucosal barrier injury Dysbiosis (microbiome imbalance) and chronic GI inflammation Micronutrient deficits that impair antioxidant defense and immune regulation High stress physiology with poor sleep and autonomic dysregulation Infections that drive immune activation in genetically susceptible hosts Environmental toxins that increase inflammatory burden Gut health is central because a large portion of immune regulation occurs at the gut-immune interface