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For example, rat TDSCs treated with IGF-1 (1, 10, and 100 ng/mL) for 28 days exhibited the increased expression of tendon-specific marker (SCX) and significantly decreased expression of chondrogenic and osteogenic marker (collagen type II) ( in vitro culture with significant upregulation of tenocytic markers (SCX, collagen type III, and decorin) ( in vivo data are available regarding the efficacy of exogenously delivery of IGF-1 in combination with stem cells to treat tendon injury
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That same pilot study found natural killer (NK) cell activity, a frontline part of your immune system, increased by as much as 400% at the two-week mark, alongside a 60% rise in lymphocyte proliferation
Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts
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