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Under normal circumstances, more than 90% of bile acids are reabsorbed in the small intestine and transported back to the liver, a process referred to as enterohepatic circulation

On 7 April, the FDA published several warning letters, including a batch to companies that the agency said are marketing GLP-1 products, dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) products, and triple agonist (GLP-1/GIP/glucagon) products without regulatory approval

Recent findings further support this mechanism, demonstrating that chronic unpredictable mild stress (CUMS) induces dysbiosis of the gut microbiota, which in turn activates central inflammatory responses

Thus, the neuroprotective effects exhibited by curcumin in preclinical TBI models can be attributed to its ability to modulate oxidative stress, neuroinflammation, mitochondrial dysfunction, and autophagy