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This enzymatic degradation substantially reduces the amount of intact glutathione that reaches the bloodstream, limiting the therapeutic concentration available to cells and tissues throughout the body

Research by Pickart and Margolina (2018) in the International Journal of Molecular Sciences showed that GHK-Cu modulates approximately 31% of human gene expression, activating 59% of affected genes and suppressing 41%

10.1002/ana.24497 70 FumagalliM.LeccaD.CoppolinoG

Homogenates were centrifuged at 800 g for 10 min at 4 C, and the supernatant was sonicated on ice for 20 s before protein quantification (BCA protein assay, Pierce, Rockford, IL, USA)