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Likewise, MPTP is metabolized into the toxic cation 1-methyl-4-phenylperydinium (MPP + ) [156] by the enzyme MAO-B of glial cells, specifically astrocytes, provides that high-affinity for MPP + affects dopamine transporter (DAT)

The hippocampus shows reduced functional connectivity bilaterally to widespread regions, including the fusiform gyrus, frontal gyrus, temporal gyrus, anterior and posterior cingulate gyri, medial frontal gyrus, precuneus, and inferior parietal lobule, compared to healthy controls [105]

The novel triple-agonist mechanism means less long-term safety data is available

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