Additionally, non-oxidative pathways regulated by fatty acid ethyl ester synthase and phospholipase D are involved in the generation of fatty acid ethyl esters and phosphatidylethanol ( However, chronic excessive alcohol consumption leads to significant metabolic disruptions: (1) Disruption of the NADH/NAD + Ratio: This imbalance enhances respiratory chain activity, increases oxygen consumption, and promotes ROS formation (Yang et al., 2022)
An imbalance between oxidants and antioxidants in favor of the oxidants is termed oxidative stress. Oxidative stress has been related to the development of several diseases such as Alzheimer's disease (Christen, 2006), diabetes (Giugliano et al., 2006), and neuronal degeneration (Cookson and Shaw, 2006)
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Moonens K, Hamway Y, Neddermann M, Reschke M, Tegtmeyer N, Kruse T, Kammerer R, Mejas-Luque R, Singer BB, Backert S, Gerhard M, Remaut H (2018) Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs