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Significantly, cardiolipin peroxidation products (e.g., hydroxyalkenal-modified CL) act as specific signaling molecules promoting cytochrome c (Cyt c) dissociation from the inner membrane and subsequent cytosolic release, constituting a event in mitochondrial apoptosis initiation

However, our previous study revealed that fusion-expressed multivalent nanobodies exhibited reduced affinity, possibly due to the spatial structure blocking the binding epitope 13

doi: 10.1007/s12020-014-0399-3 104 ValeaAGeorgescuCE