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INH is a prodrug that enters the Mtb cytoplasm via passive diffusion, where it inhibits mycolic acid synthesis by targeting the InhA enzyme, an essential catalyst in an early step of the mycolic acid biosynthetic pathway (Mitchison, 1956)

doi: 10.1080/09712119.2017.1332632 17 AlhussienMNDangAK

A non-transgenic mouse model (icv-STZ Mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD Mouse)

Concurrently, leucine, which is categorized as a branched-chain amino acid, serves as a powerful activator of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, thereby promoting MPS and mitigating the effects of muscle atrophy (12, 13)