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Swedish Metabolomics Centre, Ume, Sweden (www.swedishmetabolomicscentre.se) is acknowledged for help with methodology standadization and quantification of pyroglutamic acid Kynurenine and tryptophan by LC-MS

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Selection of candidate mutants Upon massively parallel sequencing of our samples, we determined the enrichment and depletion of each variant within the treatment populations relative to the untreated control population

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