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K.et al (2020)

The low IGF-I levels is caused by nutritionally acquired hepatic GH resistance from intra-portal hypoinsulinemia ( Table 1

resolves between titrations Week 58 (retatrutide ~1 mg/week) Steady weight-loss rate (community-reported 12 lb/week) "Food noise" reduction strongest at this dose GI side effects easing as the body adapts to the stable dose Week 912 (retatrutide ~2 mg/week, maintenance entry point) Stable weight-loss curve Rate of loss consistent with retatrutide Phase 2 trajectory This is the reported entry point for adding cagrilintide By month 3, community-reported total weight loss on retatrutide alone clusters around 610%