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doi: 10.3389/fpain.2025.1593908 Received 14 March 2025 Accepted 28 April 2025 Published 13 May 2025 Volume 6 - 2025 Edited by Otilia Obreja, Zentrum fr Schmerz und Stresserkrankungen, Switzerland Reviewed by Evelyne Silva Brum, Federal University of Rio Grande do Sul, Brazil Updates Copyright 2025 Ho, Ryan and Holle

Synapse Pro (25mg capsule, 30-count): A higher-dose formulation for patients who have demonstrated good tolerance on the 5mg protocol for at least 4 to 6 weeks and want to pursue a more aggressive cognitive enhancement timeline, or for patients whose provider determines a higher starting dose is clinically appropriate based on their specific presentation

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