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PDRN, EGF analogs, GHK-Cu, and the mid-to-high MW HA fractions all need active delivery, not passive diffusion across a closing channel

Fas/FasL-mediated apoptosis pathway at the mitochondrial level Different triggers, including cytotoxic chemotherapy, UV radiation, the removal of growth factors, or the activation of p53, can lead to mitochondrial dysfunction followed by apoptosis

Discussion: Our findings suggest that CB-839 has limited efficacy in CLL treatment and shows limited synergy in combination with widely used CLL drugs

Kemper designed and conducted the study, analysed the data, interpreted the results and prepared and finalised this drafted manuscript