Yet, riboflavin supplementation is increasingly explored in specific clinical settings, for example in case of preeclampsia 24 , anemia during pregnancy 25 , Parkinsons disease and migraine 26 , and female 27 , and postpartum depression 28 , as further discussed below
However, the phenomena that induce OS attributable to the patients aging, in addition to being variable in terms of intensity among individuals, are difficult to distinguish from those produced by the compromised antioxidant defense systems due to a neurodegenerative disease, such as ALS
As discussed, the interplay between astrocytes and microglia via modulation of GSH activity implies that GSH is not only a cellular antioxidant, but an important mediator of cross-talk between resident CNS immune cells
DOI: 10.1016/j.jprot.2009.08.010 95