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OC is a complex disease that can be classified into five main subtypes: HGSOC, low-grade serous OC, serous, clear cell and mucinous (52)

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Women with PCOS exhibit elevated serum and follicular fluid levels of citrullinated histone H3 (citH3) and neutrophil elastase compared with age- and BMI-matched controls, correlating with insulin resistance, hyperandrogenism, and systemic inflammation [5]