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M.VestergaardE.JessenN.Kolind-ThomsenP.NellemannB.NielsenT.et al (2019)

This receptor acts as a pattern-recognition receptor that initiates specific cell signaling ( In addition to the pathways mentioned above, hyperglycemia also genetically regulates inflammation in endothelial dysfunction

Studies focus on its ability to stimulate fibroblasts to increase the production of Type I and Type III collagen and glycosaminoglycans, enhancing the structural framework of the skin in vitro