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When melanin production goes into overdrive in a specific spot, that area turns darker than the skin around it

However, this concept must be modified, because it is now known that certain conjugation reactions (acyl glucuronidation of nonsteroidal anti-inflammatory drugs, O -sulfation of N -hydroxyacetylaminofluorene, and N -acetylation of isoniazid) may lead to the formation of reactive species responsible for the toxicity of the drugs