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Premarket FDA review of modified risk products is critical for the agency to determine whether the product, as used by consumers, will significantly reduce the risk of disease to individual users and to assess whether its marketing, with the claim of reduced risk, will benefit the health of the population as a whole

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In addition, the e-cigarette lacks any buttons and controls - insert the cartridge and start vaping

However, this dose-response relationship is not entirely linear, as even light smoking can substantially elevate risk, suggesting that using pack-years as an indicator may not fully capture smoking-related harm