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Description

NSAIDs cause topical mucosal damage by inhibiting COX-1, resulting in a decreased level of prostaglandins, which protect the gastric mucosa, and thereby resulting in damage in both the upper and lower gastrointestinal tracts (GITs) [12]

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The resultant reduction in cAMP leads to decreased cAMP-dependent protein kinase (PKA) activity and diminished phosphorylation of pyruvate kinase and phosphofructokinase-2, PFK-2

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Guyenet SJ, Furrer SA, Damian VM, Baughan TD, La Spada AR, Garden GA

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