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Using in vitro cultured NSCs from the SVZ of 8-day-old mice, they revealed a remarkable depletion in immature neurons over time in the culture, which was related to the decrease in microglia numbers as opposed to NSCs [94]

Thus, the mutation has survived in the genome in areas where malaria is (or was) prevalent (Africa, Middle East, India, and Southeast Asia)

The human clinical trial gap: As of this writing, no published randomized, placebo-controlled human clinical trial has evaluated BPC-157 for any indication