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[39] [40] RSSR' + 2 GSH RSH + R'SH + GSSG where R and R' are parts of the micro-nanogel structure, and GSSG is oxidized glutathione (glutathione disulfide)

Off-spec benzyl alcohol levels, plastic containers, missing manufacturers, and even mislabeled saline have all shown up in this category

However, excessive accumulation of ROS can lead to oxidative stress, causing damage to cellular components (e.g., DNA, proteins, and lipids), and potentially contributing to various diseases

Hypersensitivity can occur with other NSAIDs, in fact the condition is actually referred to as NSAIDs exacerbated respiratory disease (NERD)