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In the past, when oral contraceptives contained relatively high amounts of estrogens, studies estimated the relative risk for hepatic adenomas as 2.5 times greater for women who had taken oral contraceptive pills for 3 to 5 years compared with women who had taken them for 1 year or less

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Berryman and colleagues revised IGF-1 actions on obesity, and concluded that this molecule possesses direct effects on muscle glucose uptake [160]