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This stress damages essential cellular components, including lipids, proteins, and DNA, potentially culminating in oxidative cell death

It is that powerful because its by far the most abundant antioxidant produced by the human body

After incubation (10 min, 39C), the plates were centrifuged (200 x g, 5 min, 20C, Universal 320, Hettich, Tuttlingen, Germany) and the medium was replaced with pre-warmed XF Seahorse medium supplemented with glucose, sodium pyruvate and glutamine (all purchased from Agilent, Santa Clara, California, USA)

Ferroptosis fundamentally differs from conventional cell death mechanisms such as apoptosis, necrosis, and autophagy