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Despite their central role in immune sensing, cytokine production, and hepatocyte communication, few studies have directly examined the combined effects of alcohol, hepatic macrophages, and HBV, limiting mechanistic understanding of how alcohol accelerates viral persistence and disease progression

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Briefly, recombinant PDI protein (0.4 M) was incubated with indicated compounds at 37 C for 1 h in sodium phosphate buffer (100 mM sodium phosphate, 2 mM EDTA and 8 M DTT, pH 7.0)

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