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a P.E.G: Polyethylene glycol b P.G: Propylene glycol c S.M.O: Sorbitan mono oleate d S.F.S: Sodium formaldehyde sulfoxylate Shelf Life Determination Instead of the well-known Arrhenius Equation, a recent ICH guideline for shelf life determination introduces a new real time data method with no extrapolation
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187,188,189 In CCl 4 -induced liver injury, deletion of YAP/TAZ in BECs hinders the recruitment of phagocytic macrophages, impairing necrotic cell clearance and ultimately leading to regeneration defects at injury sites
Exposing cerebral mitochondria to THC was reported to induce a ten-fold increase in free radical leak and increased H 2 O 2 production [40], while in epithelial cells, THC upregulated inflammation-related genes and downregulated antioxidant-related genes [34]
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