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Given the thin evidence base and the absence of large controlled trials, caution is warranted, and consultation with a qualified physician is strongly recommended

Clinical experience suggests that the maximum dose range of semaglutide (2.4 mg) roughly corresponds to the 10-15 mg range of tirzepatide, but individual response varies significantly

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The first human safety study on health volunteers was conducted in 2002 and a phase 2 double blind, randomized clinical trial (small and not sufficient for US phase 2 purposes) was conducted in 2005 with BPC-157 enemas for ulcerative colitis, with some promising effects (see research name PL 14736 to find the references)