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Although the nanoparticle drug delivery system was not initially designed for LDL-receptor-mediated brain targeting, it was later found that apolipoprotein E would be absorbed on the polysorbate 80 coated nanoparticles upon incubation of the nanoparticles with human plasma resulting in LDL-receptor mediated BBB crossing

Short answer: It appears tolerable in very limited early human data, but there is not enough evidence to call it safe for general use

However, additional research endeavors are necessary to thoroughly comprehend its mechanism of action on patellar tendonitis fully and optimize its medical use within this specific context

By using B12 instead of just corticosteroids, patients benefit from reduced side effects without compromising effective pain relief