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LPO occurs as a chain reaction between polyunsaturated fatty acids and ROS, leading to the generation of lipid peroxides and hydrocarbon polymers, which are both highly toxic to the cell

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The effect of Sal A on transsulfuration pathway and this pathway-dependent GSH synthesis found in this study provides a new sight into the antioxidant effect of Sal A besides its catechol structures and is suggested to be one of the multiple mechanisms accounting for the potential beneficial effects of Sal A