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Glucose may be a limiting factor, required to support multiple cell types in the inflamed synovial membrane, while glutamine may be freely accessible, excluding the proliferative FLS from glucose competition

10.1093/humupd/dmv016 60 InoueY.MunakataY.ShinozawaA.Kawahara-MikiR.ShirasunaK.IwataH

For instance, transcriptomic studies have revealed that several SIGGP and SIGME genes are upregulated during the breaker and ripening stages, coinciding with peak AsA levels

This increased activity naturally leads to higher levels of oxidative stressa condition where the body has more free radicals than it can easily neutralize