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Further oxidation of Hz and AcHz by CYP450 enzymes, particularly CYP2E1, generates reactive intermediates that form covalent adducts with endogenous macromolecules, a process implicated in INH-induced hepatotoxicity (Yue et al., 2004

They include the drug varenicline and nicotine replacement therapy (NRT), such as patches and gum

Based on reporting by the Associated Press

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