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1 Introduction Multiple sclerosis (MS), an immunoinflammatory disease, is caused by the chronic demyelination of nerve axons and, thus, disrupts the function of the central nervous system (CNS), eventually leading to severe disability, such as autonomic dysfunction, paralysis, disability of motor control, and cognitive impairment of the brain (www.atlasofms.org), which is compiled and updated by the Multiple Sclerosis International Federation (MSIF), it is estimated that 2.8 million people are affected by MS worldwide

34 CassanoT.ServiddioG.GaetaniS.RomanoA.DipasqualeP.CianciS.et al (2012)

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Effectiveness of soft tissue massage and exercise for the treatment of non-specific shoulder pain: a systematic review with meta-analysis