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The model was defined by two differential equations: A and C are the amounts of drug in the depot and central compartments, k a and k el are the first-order absorption and elimination rate constants, V/F is the volume of distribution, F is the bioavailability (assumed equal to one), and Cp is the drug concentration in the central compartment

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The performance of each model was compared by examining how close the predicted solutions were to the experimental OCR data using the penalised-likelihood AIC and BIC criteria