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In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)

Its morphological hallmarks include cell shrinkage, chromatin condensation, and formation of apoptotic bodies [15]

It suggests BPC-157 could improve benzodiazepine efficacy during chronic treatment, potentially allow lower therapeutic doses, and ease withdrawal when discontinuing benzodiazepines