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The randomised controlled trial included 90 CHB patients, who were randomly assigned to receive either entecavir alone (control group) or entecavir plus reduced glutathione (observation group) for three months

The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females

However, limitations such as variable patient responses, potential side effects, and the need for individualized treatment plans highlight the ongoing challenges in treating liver cirrhosis effectively

Common adverse effects encountered include pruritus, erythema, and burning sensation, which can be seen more with tacrolimus, but generally subsides over time