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Over time, mutated mtDNA molecules can undergo clonal expansion, and once the mutational burden exceeds a critical thresholdtypically 60% and 90% they produce a biochemical defect in OXPHOS, a concept referred to as the mtDNA mutational load (112)

Its the same issue

In rodents, especially mice, the increased DNA content that represents the biochemical effect of hyperplasia may occur by changes in cellular ploidy without actual cytokinesis