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Compared to people who never smoked, those who smoked between just one to 14 cigarettes a day had a 21-fold increased risk of dying from chronic lung disease, a 13-fold increased risk of dying from lung cancer and double the risk of dying from coronary heart disease during the follow-up period

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Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century, Arch Toxicol 88 (1): 5-7

But many smokers simply looked across the border to get their fix