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Simmons as B.R., Nick's boss Robert Duvall as the Captain, founder of the Academy for Tobacco Studies Kim Dickens as Jill Naylor, Nick's ex-wife Connie Ray as Pearl Todd Louiso as Ron Goode Marianne Muellerleile as Joey's school teacher Dennis Miller as himself Melora Hardin as Interviewer Daniel Travis as Brad, Jill's current partner Director Jason Reitman asked many of his prospective actors and actresses to be in the film by writing each of them a personal letter

First Things First provides grants to smaller community groups and parents to help with things like improving childcare and ensuring children are ready for kindergarten

Early detection improves the chances of successful treatment, as throat cancer is most treatable in its early stages