doi: 10.1016/j
Chemotherapy is most successful at treating rapidly proliferating tumors, such as certain leukemias, lymphomas, and testicular tumors, as well as smaller tumors that are growing rapidly (Baszkowsky 2012
Benefit 6: Reduces Chronic Inflammation Chronic inflammation underlies many illnesses, including autoimmune diseases, vector-borne illnesses like Lyme disease and co-infections, IBD, and lung conditions like asthma, COPD, cystic fibrosis
Based on the working hypothesis of P-gp-dependent collateral sensitivity [14,15,16,17], we examined the ability of tamoxifen as a collateral sensitivity drug for two reasons: a) tamoxifen has been previously shown to activate P-gp ATPase at clinically achievable concentration (46 M) [20, 21], and b) tamoxifen is widely used in the treatment of estrogen receptor-positive breast cancer [22]