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A lot of the evidence so far is in vitro (done on cells in a lab dish) or from small studies, rather than large, controlled trials on real skin over time

Some studies describe occasional localized redness or mild irritation during topical research applications, while systemic toxicity has not been observed at commonly investigated research concentrations

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Especially if you have a history of feeling extra sore after a vaccine injection, its suggested to take over-the-counter (OTC) pain relievers around two hours before your appointment