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Although adverse reactions to intravenous, intramuscular or subcutaneous injection of 0.9% benzyl alcohol are not known to occur in man, experimental studies of small volume parenteral preparations containing 0.9% benzyl alcohol in several species of animals have indicated that an estimated intravenous dose up to 30 mL may be safely given to an adult without toxic effects

Additionally, TTM inhibits TNF--induced activation of NF-B and AP-1, leading to the suppressed expression of adhesion molecules (VCAM-1 and ICAM-1) and the chemokine MCP-1

This study uncovers a novel mechanism underlying tinnitus and lays the groundwork for the development of therapeutic and preventive strategies