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This effect was likely due to attenuation of spinogenesis promoted by HGF and Dihexa treatments since, without the antagonizing effect of Hinge, each agonist increased mini-AMPA frequencies (Figure 13 A-B and Figure 10) thus forming functional synaptic connections

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An increased ROS load with unaugmented Gpx/GR ratio was also modelled to demonstrate the behaviour of a system that did not have higher Gpx concentration compared with GR, as would occur without introduction of our plasmid containing the enzymes in series