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In another study, the 5-methyl-THF content in blanched vegetables decreased with the time of frozen storage at 18 C by 98% in cauliflower, 24% in broccoli, 39% in peas and spinach just after 3 months, and by 8298% in all of them after 6 months

Mice did not show a decrease in fecal output following morphine injection was excluded from the analysis due to individual differences in morphine-induced constipation

Liu J, Lou Y, Wu B, Mui A

Reported side effects in human anecdotal use are generally mild and may include: Mild nausea, particularly with oral administration Redness, itching, or irritation at the injection site Temporary dizziness or mild headache Changes in appetite or weight A significant theoretical concern revolves around its pro-angiogenic properties