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Taxier et al., 2022), TgF433-AD rats (Pentkowski et al., 2018), Wistar rats injected with intracerebroventricular streptozotocin to induce sporadic AD (Roy et al., 2022), and THY-Tau22 (which expresses human 4-repeat tau mutated at sites G272V and P301S under a Thy1.2-promotor) (Schindowski et al., 2006), also display increased anxiety-like behaviors

For example, if a certain substance is known to greatly slow down one of these enzymes, then any drug broken down by that enzyme will be present in the bloodstream in far higher amounts, leading to overdose

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2a, b), although they were decreased in frequency and numbers (Supplementary Fig