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Superoxide radical generation is caused by the reaction catalyzed by the superoxide dismutase (SOD) activity: In plant cells, multiple sources caused the production of H 2 O 2 such as the electron transport chain (ETC) in mitochondria or chloroplasts, cell membrane, endoplasmic reticulum (ER), photo-respiration, and lipid peroxidation

Weekly administration of the same molecule for 4 weeks in a second study with obese hypertriglyceridemic subjects demonstrated similar effects on triglycerides, HDL- and non-HDL cholesterol, and adiponectin, but without affecting body weight (293)

Gloy VL, Briel M, Bhatt DL, Kashyap SR, Schauer PR, Mingrone G, et al

Apixaban already carries bleeding risk